Current Issue : April-June Volume : 2013 Issue Number : 2 Articles : 2 Articles
With the objective of reducing analysis time and maintaining good efficiency, there has been substantial focus on high-speed chromatographic separations. Recently, commercially available ultra-performance liquid chromatography (UPLC) has proven to be one of the most promising developments in the area of fast chromatographic separations. In this work, a new isocratic reverse phase chromatographic method was developed using UPLC for Ziprasidone Hydrochloride Monohydrate. The newly developed method is applicable for assay determination of the Ziprasidone in capsule dosage form. The chromatographic separation of Ziprasidone was achieved on a Zorbax SB C-8 (50 x 4.6) mm, 3.5 µm column within a short runtime of 2 min. The method was validated according to the International Conference on Harmonization [ICH] guidelines with respect to specificity, precision, linearity, accuracy, range, stability of analytical solution, robustness and system suitability....
The objective of the present investigation was to study the influence of different solvents employed for recrystalization of ibuprofen on physicochemical properties of recrystalized ibuprofen crystals. Ibuprofen was recrystallized with methanol, isopropanol, chloroform and ether by maintaining similar conditions. Marked differences in crystal habit of the samples obtained from these solvents were observed. More particularly, crystallization provided an improved process for preparing large size crystals of ibuprofen, lower bulk volume, and improved flow properties, faster solubility properties. The samples crystallized from methanol had a polyhedral crystal habit, while those from isopropanol and chloroform were elongated crystals and the crystals obtained from ether are cubical. Samples obtained from ether exhibited greater solubility. Sample obtained from isopropanol exhibited greater porosity. Samples obtained from methanol exhibited highest bulk density and best flow rate....
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